2月25日，北京康復醫院研究人員聯合淄博、青島學者在預印本平臺medRxiv發表的一項覆蓋5萬多例新冠肺炎感染者的Meta分析顯示，發熱和咳嗽是新冠肺炎感染者最常見的症狀，近97%的患者胸部CT檢查異常。
作者還從專業角度指出，作者認為，肺纖維化或將成為新冠肺炎患者的併發症之一。如何預防和減少肺纖維化的發生將成為重要課題。
本研究通過搜索PubMed，Cochrane Library，Embase和其他數據庫。收集了10個有關2019-nCoV感染臨床特徵的研究以進行Meta分析，涉及50466例患者。
Clinical characteristics of 50466 patients with 2019-nCoV infection
Pengfei Sun, Shuyan Qie, Zongjan Liu, Jizhen Ren, Jianing Jianing Xi
doi: https://doi.org/10.1101/2020.02.18.20024539
Abstract
Objective: We aim to summarize reliable evidences of evidence-based medicine for the treatment and prevention of the 2019 novel coronavirus (2019-nCoV) by analyzing all the published studies on the clinical characteristics of patients with 2019-nCoV. Methods: PubMed, Cochrane Library, Embase, and other databases were searched. Several studies on the clinical characteristics of 2019-nCoV infection were collected for Meta-analysis. Results: Ten studies were included in Meta-analysis, including a total number of 50466 patients with 2019-nCoV infection. Meta-analysis shows that, among these patients, the incidence of fever was 89.1%, the incidence of cough was 72.2%, and the incidence of muscle soreness or fatigue was 42.5%. The incidence of acute respiratory distress syndrome (ARDS) was 14.8%, the incidence of abnormal chest computer tomography (CT) was 96.6%, the percentage of severe cases in all infected cases was 18.1%, and the case fatality rate of patients with 2019-nCoV infection was 4.3%. Conclusion: Fever and cough are the most common symptoms in patients with 2019-nCoV infection, and most of these patients have abnormal chest CT examination. Several people have muscle soreness or fatigue as well as ARDS. Diarrhea, hemoptysis, headache, sore throat, shock, and other symptoms only occur in a small number of patients. The case fatality rate of patients with 2019-nCoV infection is lower than that of Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS).
來源：Clinical characteristics of 50466 patients with 2019-nCoV infection. medRxiv preprint https://doi.org/10.1101/2020.02.18.20024539
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