原創 MNT 醫學營養MNT 1周前
使用常規線性模型設計進行功能磁共振成像的結果，以評估最高負荷與最低負荷下的的BOLD活動(3-back > 0-back)。
對西班牙巴塞羅那和加利福尼亞洛馬琳達的老年人進行2年核桃與健康老齡化研究，隨機分配708名自由活動的老年人（63-79歲，68％的女性），以能量約15％（30-60 g / d）的核桃仁飲食或對照飲食（核桃仁）。在基線和2年時，對研究對象進行了全面的神經認知測試。整體認知複合體的變化是主要結果。對108名巴塞羅那參與者進行了重複的結構和功能性腦部MRI檢查。
共有636名參與者完成了干預。除了營養攝入量方面的差異外，來自巴塞羅那的參與者比洛馬·琳達的參與者吸菸更多，受教育程度較低並且基線神經心理測試得分較低。核桃的耐受性良好，順應性良好。修改後的意向性治療分析（n = 657）未發現整體認知複合物中的組間差異，核桃飲食組的平均變化為-0.072（95％CI：-0.100，-0.043），而對照飲食組為-0.086（95％CI：-0.115，-0.057（P = 0.491）。事後分析顯示，巴塞羅那隊列有顯著差異，核桃組未經調整的變化為-0.037（95％CI：-0.077，0.002），對照組為-0.097（95％CI：-0.137，-0.057）（P = 0.040）。巴塞羅那參與者的一部分大腦功能磁共振成像的結果表明，在對照組的工作記憶任務中，功能性網絡的募集能力更大。
補充核桃2年對健康老年人的認知沒有影響。然而，大腦功能磁共振成像和事後事後分析表明，核桃可能延遲高風險亞組的認知能力下降。這些令人鼓舞但不確定的結果值得進一步調查，特別是針對弱勢群體，他們有望獲得最大的利益。
資料來源
The American Journal of Clinical Nutrition,
Volume 111, Issue 3, March 2020, Pages 590–600,
ID：doi.org/10.1093/ajcn/nqz328
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