作者：Tabacco S ,et al.
翻譯: 河北保定解放軍82集團軍醫院 劉振華
譯者簡介：劉振華，碩士研究生，河北保定解放軍82集團軍醫院（原解放軍252醫院）中醫康復科主治醫師，現任中國中醫藥研究促進會青年醫師分會委員，保定市風溼病學專業委員會委員。2019年於北醫三院進修，師從劉湘源教授，系統學習免疫性不良妊娠的診斷及治療。
【摘要】
在過去的二十年中，使用低分子量肝素和低劑量阿司匹林的常規治療，抗磷脂綜合徵婦女的妊娠預後顯著改善。然而，儘管如此，10-15%的抗磷脂綜合徵患者仍然經歷了妊娠損失。
確定預測併發症的危險因素，已經進行了幾項研究。血栓形成已被普遍認為是妊娠發病的關鍵機制。然而，單純的血栓形成狀態並不能解釋導致妊娠失敗的所有機制。
事實上，新的證據表明補體途徑在抗磷脂綜合徵的臨床事件中起著重要的介導作用。然而，補體介導抗磷脂綜合徵併發症的確切機制尚不清楚。多項的研究表明，低補體水平（C3和C4）與抗磷脂綜合徵婦女的不良妊娠結局相關。
低補體血癥可作為不良妊娠結局的早期預測指標，如有必要，在妊娠初期可作為常規治療的補充治療。然而，我們需要進一步研究以便更好地瞭解低補體水平對抗磷脂綜合徵妊娠結局的影響。
附原文
ABSTRACT: Prognosis of pregnancies in women with antiphospholipid syndrome has dramatically improved over the past two decades using conventional treatment with low molecular weight heparin and low-dose aspirin. However, despite this regimen, 10-15% of antiphospholipid syndrome patients experience pregnancy losses. Several studies have been performed in order to identify risk factors predictive of complications. Thrombosis has been generally accepted as the key pathogenetic mechanism underlying pregnancy morbidity. However, the thrombogenic state alone is not able to explain all the different mechanisms leading to pregnancy failure. In fact, emerging evidence shows that complement pathway could play an important role in mediating clinical events in antiphospholipid syndrome.
However, the exact mechanism through which complement mediates antiphospholipid syndrome complications remains unknown. Low complement levels (C3 and C4) are associated with poor pregnancy outcome in women with antiphospholipid syndrome in different studies. Hypocomplementemia could be indicated as an early predictor of adverse pregnancy outcome, available at the beginning of pregnancy for starting, if necessary, additional treatment to conventional therapy. However, future studies need to better understand the impact of low complement level >
引自
Tabacco S; Giannini A; Garufi C; Botta A; Salvi S; Del Sordo G; Benedetti Panici P; Lanzone A; De Carolis S. Complementemia in pregnancies with antiphospholipid syndrome.
. Lupus.2019;DOI: ；1503-1509.
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