靶向治療急性髓細胞性白血病的新方案

的研究,該研究找到了可以同時作用於CKIα和轉錄激酶CDK7/9的藥物小分子,並在臨床前模型中可用於治療AML。Cell, 2017. 168(4): p. 629-643.

3. Papaemmanuil, E., et al., Genomic Classification and Prognosis in Acute Myeloid Leukemia. N Engl J Med, 2016. 374(23): p. 2209-2221.

4. Petzold, G., E.S. Fischer, and N.H. Thoma, Structural basis of lenalidomide-induced CK1alpha degradation by the CRL4(CRBN) ubiquitin ligase. Nature, 2016. 532(7597): p. 127-30.

5. Barabe, F., et al., Modeling the initiation and progression of human acute leukemia in mice. Science, 2007. 316(5824): p. 600-4.

6. Ferguson, F.M. and N.S. Gray, Kinase inhibitors: the road ahead. Nat Rev Drug Discov, 2018. 17(5): p. 353-377.

靶向治療急性髓細胞性白血病的新方案

靶向治療急性髓細胞性白血病的新方案

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